PANAGENE has developed a PIK3CA mutation detection kit that utilizes PNA-mediated real-time PCR clamping technology.
Detecting PIK3CA mutation has been important in cancer research since its mutation detected in various types of cancer such as brain, ovarian and lung cancer. The presence of PIK3CA mutations can be considered a useful prognostic factor that may also predict the outcome of the treatment.
PIK3CA can not be detected by direct sequencing, because of the presence of pseudogene which has 97 % of homology. However, PNAClamp¢â PIK3CA Mutation Detection Kit, where wild type matched PNA probe suppresses the amplification of the pseudogene, provides a reliable solution to the pseudogene problem in PI3 kinase gene.
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