Expert Opin Biol Ther. 2009 Aug;9(8):975-89.

Prospects for antisense peptide nucleic acid (PNA) therapies for HIV.

Pandey VN, Upadhyay A, Chaubey B.
University of Medicine and Dentistry, New Jersey-New Jersey Medical School, Department of Biochemistry and Molecular Biology, Newark, NJ 07103, USA. pandey@umdnj.edu

Abstract
Since the discovery and synthesis of a novel DNA mimic, peptide nucleic acid (PNA) in 1991, PNAs have attracted tremendous interest and have shown great promise as potential antisense drugs. They have been used extensively as tools for specific modulation of gene expression by targeting translation or transcription processes. This review discusses the present and future therapeutic potential of this class of compound as anti-HIV-1 drugs.

PMID: 19534584 [PubMed - in process]

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