PNA probe has very high specificity and sensitivity to target DNA mainly due to electrical neutrality of its chemical structure. This trait enables PNA probes to be more efficient and useful in applying FISH (fluorescent in situ hybridization) technology even at low concentrations.
When used with PNA probes, PNA-DNA hybridization is much faster within a couple of hours and results in significantly reduced background noise due to the high signal to background noise ratio.
Cat. No. Product Name

Quantity
F1001-5 TelC-FAM 5nmole
F1002-5 TelC-Cy3
F1003-5 TelC-Cy5
F1009-5 TelC-FITC
F1005-5 TelG-FAM
F1006-5 TelG-Cy3
F1007-5 TelG-Cy5
F1010-5 TelG-FITC
F2001-5 TelC-TMR
F2002-5 TelG-TMR
Chromosome aberrations in the centromere such as trisomy, polysomy and break can be clearly detected by using PNA FISH probe.
Cat. No. Product Name Quantity
F3003-5 Cent-Cy3 5 nmole
F3006-5 Cent-FAM
1 Kentaro Taemura et al., Dynamic rearrangement of telomeres during spermatogenesis in mice. Developmental Biology. 2005;281:196-207.  
2 Won-Woo Lee et al., Age-related telomere length dynamics in peripheral blood mononuclear cells of healthy cynomolgus monkeys measured by Flow FISH. Immunology. 2002;105:458-465.  
3 Heather Perry et al., Identification of indicator microorganisms using a standardized PNA FISH method. Journal of Microbiological Methods. 2001;47:281-292.  
4 Caifu Chen et al., Single base discrimination of CENP-B repeats on mouse and human chromosomes with PNA-FISH. Mammalian Genome. 1999;10:13-18.  
5 M. Hultdin et al., Telomere analysis by flourescence in situ hybridization and flow cytometry. Nucleic Acids Research. 1998;26(16):3651-3656.  
6 Peter M. Landsdorp et al., Heterogeneity in telomere length of human chromosomes. Human Molecular Genetics. 1996;5(5):685-691.