Bioorg Med Chem Lett. 2009 Jul 1;19(13):3410-3. Epub 2009 May 15.

Carrier PNA for shRNA delivery into cells.

Kitamatsu M, Kubo T, Matsuzaki R, Endoh T, Ohtsuki T, Sisido M.
Department of Bioscience and Biotechnology, Faculty of Engineering, Okayama University, 3-1-1 Tsushimanaka, Okayama 700-0082, Japan. kitamatu@cc.okayama-u.ac.jp

Abstract

A peptide nucleic acid (PNA)-cell-penetrating peptide (CPP) conjugate (carrier PNA) was used as 'bridge-builder' to connect a CPP with an shRNA. The carrier PNA successfully formed a hybrid with an shRNA bearing complementary dangling bases and the shRNA was introduced into cells by the carrier PNA, and RNAi was induced by the shRNA.


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