* 현재 사업 중인 PANArray™ HPV Genotyping Chip과 DNA Chip의 비교 논문이 아래와 같이 BioChip journal에 게재되었습니다.
제목 :
Comparison of the performance of the PANArray™ HPV test and DNA chip test for genotyping of human papillomavirus in cervical swabs
저자 :
Hye Jong Song, Jeong Won Lee, Byoung Gie Kim, Sang Yong Song, Duk Soo Bae & Dae Shick Kim
출처 :
Received: 5 March 2010 / Accepted: 20 May 2010 / Published online: 20 September 2010
The Korean BioChip Society and Springer 2010
발행연도 : 2010
주제키워드 : PNA, PNA microarray, Human papillomavirus(HPV), HPV genotyping
초록(영문) :
The aim of this study was to evaluate the recently developed PANArrayTM Human papilloma virus (HPV) kit for detection and genotyping of 19 high-risk and 13 low-risk HPV types, and compare it with the commercially available DNA chip kit genotyping of 24 HPVs. We collected cervical swabs from 741 patients with various stages of invasive cervical
carcinoma being treated at the Samsung Medical Center. The overall HPV positivity rate was 73% using PANArrayTM HPV and 72.1% with the DNA chip, and no statistically significant differences were found with respect to the cytology grade. Comparing the results of the two chips, concordant results were found in 637/741 samples (85.9%), compatible in 69/741(9.3%) and discordant in 35/741 (4.7%). Type-specific sequencing analysis of all samples revealed a 99.7% confirmation of PANArrayTM HPV genotyping results, compared to 91.0% of DNA chip. The PANArrayTM HPV test thus proved to be highly sensitive and accurate even when multiple HPV infections were present.
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